gastroplustm v9.8 (Simulations Plus Inc)
Structured Review
Gastroplustm V9.8, supplied by Simulations Plus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gastroplustm/gastroplustm+software/pm39961585-43-0-2
Average 90 stars, based on 1 article reviews
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Formulation:Article Title: SeDeM expert system with I-optimal mixture design for oral multiparticulate drug delivery: An encapsulated floating minitablets of loxoprofen Na and its in silico physiologically based pharmacokinetic modeling Article Snippet: .. Firstly, for this purpose, the pharmacokinetic data of loxoprofen sodium (immediate-release tablet; 60 mg) formulation from 24 healthy male Korean volunteers was obtained from the study by Kang et al. (2011) (extracted data is given in ) and was further processed in the PKPlusTM module of Drug discovery:Article Title: Schiff bases of 4-Phenyl-2-Aminothiazoles as hits to new antischistosomals: Synthesis, in vitro, in vivo and in silico studies. Article Snippet: The treatment of schistosomiasis is based on a single drug, the praziquantel (PZQ), an oral bioavailable and efficient agent which causes minimal side effects.. The main concern about this approach, however, is that relying on only one drug to treat a helminthic disease is a dangerous strategy since history shows that pathogens easily evolve to resistant forms.. Actually, reports about experimental strains exhibiting low sensibility to PZQ can be found in literature. Permeability:Article Title: Permeability evaluation of gemcitabine-CPP6 conjugates in Caco-2 cells Article Snippet: .. Some properties of these new conjugates are presented in . table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Peptide/Conjugate M W (g/mol) PSA a (Å 2 ) HBD P eff (cm/s) b (x10 -6 ) P eff (cm/s) c (x10 -9 ) P app (cm/s) (x10 -8 ) Gem-CPP6-1 1117.29 247.63 13 3.19 1.31 1.326 Gem-CPP6-2 1117.29 247.63 13 3.82 1.31 4.568 Gem-CPP6-3 1087.20 267.86 14 2.47 0.412 1.326 Open in a separate window a Polar surface area, predicted by MedChem Designer (version 3.1.0.30, Simulations Plus, Inc., Lancaster, California, USA); b Effective permeability, predicted by |
