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gastroplustm v9.8  (Simulations Plus Inc)

 
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    Simulations Plus Inc gastroplustm v9.8
    Gastroplustm V9.8, supplied by Simulations Plus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gastroplustm v9.8/product/Simulations Plus Inc
    Average 90 stars, based on 1 article reviews
    gastroplustm v9.8 - by Bioz Stars, 2026-04
    90/100 stars

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    Model simulations of vancomycin concentration-time profiles from four studies in the training dataset: (A) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young US population. (B) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young Chinese population. (C) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the HC group. (D) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the LC group.

    Journal: Frontiers in Pharmacology

    Article Title: High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis

    doi: 10.3389/fphar.2025.1555276

    Figure Lengend Snippet: Model simulations of vancomycin concentration-time profiles from four studies in the training dataset: (A) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young US population. (B) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young Chinese population. (C) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the HC group. (D) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the LC group.

    Article Snippet: To assess pharmacokinetics and tissue distribution of vancomycin in PJI patients, we employed the commercially available dynamic PBPK modeling software GastroPlusTM version 9.9 (Simulations Plus, Inc.) to construct a stepwise model as previously described ( ).

    Techniques: Concentration Assay, Clinical Proteomics

    The model to predict vancomycin concentrations in the red marrow, yellow marrow and kidney: (A) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the HC group. (B) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the LC group. (C) Observed and PBPK model simulated concentrations in plasma and kidney in the HC group. (D) Observed and PBPK model simulated concentrations in plasma and kidney in the LC group.

    Journal: Frontiers in Pharmacology

    Article Title: High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis

    doi: 10.3389/fphar.2025.1555276

    Figure Lengend Snippet: The model to predict vancomycin concentrations in the red marrow, yellow marrow and kidney: (A) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the HC group. (B) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the LC group. (C) Observed and PBPK model simulated concentrations in plasma and kidney in the HC group. (D) Observed and PBPK model simulated concentrations in plasma and kidney in the LC group.

    Article Snippet: To assess pharmacokinetics and tissue distribution of vancomycin in PJI patients, we employed the commercially available dynamic PBPK modeling software GastroPlusTM version 9.9 (Simulations Plus, Inc.) to construct a stepwise model as previously described ( ).

    Techniques: Clinical Proteomics